Clinical Trial

Minimal-flow Anesthesia and Cognitive Outcomes in Elderly Surgical Patients

Completed
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Summary
Purpose: Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients following major surgery and is associated with impaired attention, memory, and executive functions. Advanced age and prolonged surgical duration are among the most important risk factors. Minimal flow anesthesia has been suggested to reduce postoperative cognitive impairment by providing more stable anesthetic depth and reducing physiological stress. The aim of this study is to investigate the relationship between surgical duration and postoperative cognitive dysfunction in elderly patients undergoing surgery under minimal flow anesthesia.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2026-02-18; most recent amendment 2026-03-16.
Status change: Recruiting → Completed 2026-03-16
Trial Details
NCT Number NCT07424729
Lead Sponsor Ankara Etlik City Hospital
Conditions Postoperative Cognitive Dysfunction
Enrollment 90 participants
Start Date 2025-10-03
Primary Completion 2026-03-12 (estimated)
Study Completion 2026-03-15 (estimated)
Updated on ClinicalTrials.gov 2026-03-18