Clinical Trial

Knee Osteoarthritis Rehabilitation Through Rotational Inertia

Study acronym: KORRI
Recruiting
View on ClinicalTrials.gov →
Summary
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods. The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail. The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.
Trial Details
NCT Number NCT07424352
Lead Sponsor University of Colorado, Denver
Collaborators: NIH/NCATS Colorado CTSA Grant Number T32TR004367
Conditions Knee Arthritis, Osteoarthritis
Enrollment 60 participants
Start Date 2025-08-20
Primary Completion 2028-12-31 (estimated)
Study Completion 2029-05-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-20