Evaluating the Relationship Between Function and Structure Using Data From a GA Natural History Cohort

Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration that leads to progressive and irreversible vision loss. The course of visual decline varies widely among patients, and it is not always clear which anatomical features of the retina are associated with faster loss of vision. This retrospective observational study aims to describe the natural history of vision loss in patients with geographic atrophy who have characteristics similar to those enrolled in recent clinical trials. The study will analyze previously collected clinical and imaging data from patients followed during routine clinical care at a single center. The main goal of the study is to evaluate the relationship between changes in visual function and retinal anatomical features, such as the size and location of atrophic lesions and retinal layer integrity, using fundus autofluorescence and optical coherence tomography images. No treatments or study procedures are performed as part of this research. All data used in the study were collected during standard clinical practice and analyzed retrospectively.

NCT Number	NCT07424235
Lead Sponsor	IRCCS Ospedale San Raffaele
Conditions	Age Related Macular Degeneration (AMD), Age Related Macular Degeneration, AMD, Geographic Atrophy, Geographic Atrophy Secondary to Age-related Macular Degeneration, Geographic Atrophy (GA) Secondary to Dry Age-related Macular Degeneration (AMD)
Enrollment	60 participants
Start Date	2015-01
Primary Completion	2024-12 (estimated)
Study Completion	2024-12 (estimated)
Updated on ClinicalTrials.gov	2026-05-11