The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults

The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are: Does daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.

NCT Number	NCT07424170
Lead Sponsor	Peking University People's Hospital
Conditions	Post Operative Delirium
Enrollment	140 participants
Start Date	2026-03-15
Primary Completion	2026-12-26 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-10