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The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults

StatusRecruiting
PhaseNot specified
Started2026-07-01
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 3 months later Dec 26, 2026 → Mar 31, 2027
See other at-risk trials from Peking University People's Hospital

Amendment history

2026-09-05
Study Status, Contacts/Locations v2
Recruitment opened
Primary completion pushed: 2026-12-26 → 2027-03-31
Completion pushed: 2026-12-31 → 2027-06-30
Start dateestimated 2026-03-15→confirmed 2026-07-01
2026-03-07
Study Status, Outcome Measures v1
Re-verified, no change to tracked fields
2026-02-15
Original filing
The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are: Does daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.
Trial Details
NCT Number NCT07424170
Lead Sponsor Peking University People's Hospital
Conditions Post Operative Delirium
Enrollment 140 participants
Start Date 2026-07-01
Primary Completion 2027-03-31 (estimated)
Study Completion 2027-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-09-10