Clinical Trial

Menopausal Impact of Opportunistic Salpingectomy for Ovarian Cancer Prevention

Study acronym: MISSION-O
Not Yet Recruiting
View on ClinicalTrials.gov →
Summary
The goal of this clinical trial is to find out whether removing the fallopian tubes at the time of hysterectomy leads to an earlier menopause. The study includes women under 55 years of age who previously underwent hysterectomy as participants in the HOPPSA trial, where they were randomly assigned to either removal of the fallopian tubes or no removal. The main question is: • Does removing the fallopian tubes at the time of hysterectomy lead to an earlier menopause? Researchers will compare women who had their fallopian tubes removed during hysterectomy with women who had hysterectomy alone to see whether menopause occurs earlier after tube removal. Age at menopause will be estimated by measuring follicle-stimulating hormone (FSH) in small blood samples collected on a paper card. Participants will: * Collect 4-5 drops of blood using a finger prick * Place the drops on a paper card and mail it to the researchers * Complete an online questionnaire These steps will be done twice, one year apart.
Trial Details
NCT Number NCT07423143
Lead Sponsor Umeå University
Collaborators: Uppsala University, Karolinska Institutet, Örebro University, Sweden, Queen Mary University of London, Region Västerbotten, Göteborg University
Conditions Menopause, Opportunistic Salpingectomy
Enrollment 2,100 participants
Start Date 2026-03
Primary Completion 2029-02 (estimated)
Study Completion 2057-12 (estimated)
Updated on ClinicalTrials.gov 2026-02-20