Clinical Trial

Window of Opportunity in Preserving Laryngeal Function Trial

Study acronym: WOLF
Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
This trial will study the safety and tolerability and disease survival rates in adult patients with recurrent/metastatic (R/M) HNSCC when treated with carboplatin or cisplatin, paclitaxel, and toripalimab.
Protocol Amendment History 3 changes
critical Recruitment opened 2026-04-14
notable Primary completion pushed: 2029-03-31 -> 2029-04-30 2026-04-14
minor Completion pushed: 2031-03-31 -> 2031-04-30 2026-04-14
Trial Details
NCT Number NCT07423078
Lead Sponsor Matthew Spector
Collaborators: Coherus Oncology, Inc.
Conditions Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Locally Advanced Laryngeal Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma
Enrollment 87 participants
Start Date 2026-04-06
Primary Completion 2029-04-30 (estimated)
Study Completion 2031-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-04-13