Response to Aerobic Training in Postmenopausal Women With Exercise Intolerance.

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide and represent a major public health challenge, with growing evidence highlighting important sex-related differences in their epidemiology, clinical presentation, and pathophysiology. In particular, menopause is associated with an increased cardiovascular risk, likely due to the decline in sex hormones and related changes in cardiac structure and function, vascular properties, and metabolic regulation. Several studies show that physical activity and, more specifically, aerobic training improves exercise tolerance and quality of life in patients. However, no studies have evaluated the effects of hormonal status, despite numerous studies on healthy subjects highlighting the influence of sex hormones on cardiovascular responses to acute and chronic exercise.

NCT Number	NCT07422961
Lead Sponsor	University of Poitiers Collaborators: Elsan
Conditions	Menopause, Physical Activity, Prevention, Cardiovascular (CV) Risk
Enrollment	43 participants
Start Date	2022-09-21
Primary Completion	2025-06-24 (estimated)
Study Completion	2025-07-07 (estimated)
Updated on ClinicalTrials.gov	2026-02-27