Dexamethasone for Prevention of Postoperative Vomiting After Laparoscopic Gynecologic Surgery

Postoperative nausea and vomiting (PONV) are common and distressing complications following laparoscopic gynecologic surgery. This randomized controlled trial evaluated whether a single preoperative intravenous dose of dexamethasone reduces postoperative vomiting compared with placebo and explored patient-related risk factors associated with PONV. Women undergoing elective laparoscopic gynecologic surgery were randomly assigned to receive dexamethasone (5 mg IV) or placebo at induction of anesthesia. The primary outcome was the incidence of postoperative vomiting within 24 hours, with secondary outcomes including nausea severity, rescue antiemetic use, and postoperative recovery parameters.

NCT Number	NCT07421817
Lead Sponsor	Rawalpindi Medical College
Conditions	Postoperative Nausea and Vomiting (PONV)
Enrollment	120 participants
Start Date	2017-10-01
Primary Completion	2018-03-31 (estimated)
Study Completion	2018-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-20