Mechanical Insufflation-Exsufflation in Critically Ill Patients

Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases. However, its use in critically ill ICU patients remains inconsistent and lacks standardized guidelines. Despite growing research, current practices vary widely in patient selection, treatment protocols, and safety management, with limited high-quality evidence to support clear recommendations. To address this gap, an international, multidisciplinary Delphi consensus study is needed to establish expert-based best practices and feasible guidelines for the safe and effective implementation of MI-E in the intensive care setting.

NCT Number	NCT07420946
Lead Sponsor	Medipol University Collaborators: International Association of Non Invasive Ventilation, International Academy of Non Invasive Ventilation, International College of Experts of Non Invasive Ventilation
Conditions	Airway Clearance, Mechanical Insufflation-exsufflation, Mechanical Insufflation-exsufflation Session ( With Cough Assist), Delphi Study, Consensus, Critical Illness, Critical Care, Critical Care, Intensive Care
Enrollment	30 participants
Start Date	2026-06-10
Primary Completion	2026-09-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-17