Menopausal Hormones and Sympathetic Activation

The purpose of this study is to understand how changes in menopausal hormones like estradiol and follicle-stimulating hormone (FSH) impact sympathetic nervous system function. To do so, the investigators will use a medication to control the production of estradiol and FSH, and in some participants, add-back estradiol to isolate its effects. The investigators will measure sympathetic activation centrally (in the brain using MRI), peripherally in the nervous system, and also examine adrenergic receptor mediated control of vascular function.

NCT Number	NCT07420218
Lead Sponsor	University of Delaware
Conditions	Perimenopausal Women
Enrollment	80 participants
Start Date	2026-09-01
Primary Completion	2030-06-01 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-27