Clinical Trial

Germline Genetic Testing of the TP53 Gene

Recruiting
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Record status
This record was last updated February 19, 2026 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
This is a retrospective, observational, single-center study designed as a cohort analysis. The study population will include consecutive patients referred for genetic counseling and TP53 germline genetic testing between 2004 and 2025 at the Division of Cancer Prevention and Genetics of the IEO. The primary endpoint is to determine the overall detection rate of Pathological Variants (PVs) in the TP53 gene among individuals referred to the institute and the differences between the groups.
Trial Details
NCT Number NCT07419893
Lead Sponsor European Institute of Oncology
Conditions TP53 Gene Mutation, Multi-Gene Transcriptional Profiling, TP53 Gene Germline Mutation Carrier
Enrollment 1,940 participants
Start Date 2026-01-29
Primary Completion 2026-07 (estimated)
Study Completion 2031-01 (estimated)
Updated on ClinicalTrials.gov 2026-02-19