Clinical Trial

Role of RNA Metabolism Alterations in Persistent Immune Dysfunction After Sepsis

Study acronym: SEPSI-splice
Not Yet Recruiting
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Summary
This study includes adult ICU patients with sepsis (according to SEPSIS 3.0) or critically ill non-septic patients with severe non-infectious conditions at Louis Mourier Hospital. It is a prospective multicentre observational study aiming to describe leukocyte transcriptome changes and molecular trajectories (endotypes) during the acute, recovery, and convalescence phases of sepsis. A total of 290 participants will be included: 200 septic patients, 50 critically ill non-septic patients, and 40 control participants.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-02-11.
Trial Details
NCT Number NCT07418801
Lead Sponsor Assistance Publique - Hôpitaux de Paris
Conditions Sepsis
Enrollment 290 participants
Start Date 2026-03-01
Primary Completion 2028-03-01 (estimated)
Study Completion 2028-03-01 (estimated)
Updated on ClinicalTrials.gov 2026-02-27