Clinical Trial

Effectiveness of Malaria Vaccines in Reducing the Risk of Invasive Non-typhoidal Salmonella Disease

Study acronym: VINS
Recruiting
View on ClinicalTrials.gov →
Summary
The goal of this observational study is to learn about the impact of malaria vaccination on the risk of invasive non-typhoidal Salmonella disease in children below the age of 5. Eligible participants residing in the Kisantu Health Zone (DRC) and presenting fever are enrolled in healthcare facilities and tested for malaria and iNTS. Using a case-control (test-negative) design, the researchers will look at the malaria vaccination status of participants with and without iNTS infection to determine if the malaria vaccine protects against iNTS.
Trial Details
NCT Number NCT07416461
Lead Sponsor International Vaccine Institute
Conditions Invasive Non-Typhoidal Salmonella Disease, Malaria, Malaria Vaccine
Enrollment 10,000 participants
Start Date 2025-10-27
Primary Completion 2027-02 (estimated)
Study Completion 2027-02 (estimated)
Updated on ClinicalTrials.gov 2026-02-18