The Aim of This Study is to Compare the Effects of Two Different Topical Agents (KLOROBEN® and KLORHEX PLUS®) Used in the Surgical Extraction of Mandibular Bilateral Mesioangular Impacted Third Molars on Postoperative Pain, Edema, and Trismus.

This study aims to compare the effects of two commonly used topical mouth sprays on pain, swelling, and limitation of mouth opening after surgical removal of impacted lower wisdom teeth. A total of 40 adult patients who require the removal of both lower impacted wisdom teeth will participate in this study. Each patient will undergo two separate surgical procedures, with a healing period between them. After each surgery, one of the two topical agents will be applied to the surgical area. The order of the treatments will be randomly assigned. The study is designed so that neither the patients nor the clinician evaluating the outcomes will know which topical agent is used at each session. Pain levels, facial swelling, and mouth opening will be measured at specific time points after surgery. The results will help determine whether one topical treatment is more effective than the other in reducing postoperative discomfort and improving recovery. The information obtained from this study may contribute to improving postoperative care following wisdom tooth surgery.

NCT Number	NCT07416136
Lead Sponsor	Marmara University
Conditions	Impacted Mandibular Third Molar
Enrollment	40 participants
Start Date	2025-04-20
Primary Completion	2025-08-15 (estimated)
Study Completion	2025-10-19 (estimated)
Updated on ClinicalTrials.gov	2026-03-25