A Multi-dimensional Evaluation of the Effects of Linear Accelerator X-ray Irradiation on Red Blood Cells

This study aims to investigate the effects of linear accelerator X-ray irradiation on the structure, mechanics and functional characteristics of red blood cells recovered from patients with malignant tumors during surgery. A red blood cell damage evaluation system based on multiple-dimensional indicators is established. Through atomic force microscopy, microfluidic chips and biochemical detection methods, the changes in red blood cell membrane structure, deformability and oxygen-carrying capacity under different irradiation doses are systematically evaluated. The dose-effect relationship between irradiation dose and red blood cell damage degree is clarified, providing experimental evidence for the safe dose of irradiation processing of autologous blood during surgery.

NCT Number	NCT07416045
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Erythrocyte Destruction
Enrollment	20 participants
Start Date	2026-01-28
Primary Completion	2027-02-26 (estimated)
Study Completion	2027-02-26 (estimated)
Updated on ClinicalTrials.gov	2026-02-17