Discomfort Following Oral Biopsy Comparing Laser and Punch Biopsy

Oral biopsy is essential for diagnosing mucosal lesions such as oral lichen planus (OLP). Laser surgery offers a minimally invasive alternative to traditional techniques, but thermal effects may impact healing and postoperative comfort. The aim of this study was to compare the degree of clinical healing and postoperative discomfort between laser and punch scalpel biopsy techniques in patients with OLP. This was a single-center, parallel-group, noninferiority, randomized, blinded, controlled trial. One hundred and twelve adults with clinically and histologically confirmed OLP were randomized and allocated into two groups. Test group (diode laser) and control group (punch scalpel).

NCT Number	NCT07414797
Lead Sponsor	Catholic University of the Sacred Heart
Conditions	Oral Lichen Planus, Biopsy
Enrollment	112 participants
Start Date	2023-01-11
Primary Completion	2025-01-23 (estimated)
Study Completion	2025-03-06 (estimated)
Updated on ClinicalTrials.gov	2026-02-18