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MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal Surgery

Study acronym: MICROSURG
StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated May 5, 2026 (before its estimated May 18, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Recruitment openedv2 Show 5 more changesShow less
    • Primary completion pushed from Mar 1, 2026 to May 18, 2026
    • Study completion pushed from Apr 1, 2026 to Jun 1, 2026
    • Start date changed from estimate of Feb 1, 2026 to Feb 23, 2026
    • Secondary endpoints revised (4)
    • Site details revised
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This clinical study investigates how the subgingival microbiome changes after three different periodontal and peri-implant surgical procedures: (1) resective periodontal surgery, (2) regenerative periodontal surgery, and (3) peri-implantitis surgery. The aim is to characterize microbial shifts associated with these commonly used surgical treatments and to determine whether the type of surgery influences the recovery or disruption of the subgingival ecosystem. Adult patients with periodontitis or peri-implantitis will receive the procedure indicated for their condition. Subgingival plaque samples will be collected at baseline and at defined postoperative follow-up intervals. Microbiome analysis will be performed using next-generation sequencing (NGS), and microbial changes will be evaluated with the Subgingival Microbial Dysbiosis Index (SMDI). Insights from this study may help improve prevention, diagnostics, and treatment strategies for periodontal and peri-implant diseases.
Trial Details
NCT Number NCT07414498
Lead Sponsor University Hospital Muenster
Collaborators: dfg
Conditions
(from sponsor)		 Periodontitis, Periimplantitis
Related terms Peri-Implantitis, Periodontitis
Enrollment 84 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov