Treatment Outcomes and Complications of Three Therapeutic Approaches for Concomitant Choledocholithiasis and Cholecystolithiasis

Recruit patients with cholelithiasis with concomitant choledocholithiasis into the cohort, and assign them to undergo endoscopic transpapillary gallbladder-preserving cholecystolithotomy or ERCP plus laparoscopic cholecystectomy or conservative treatment based on patient preference. Collect clinical data and patient-reported outcomes regularly at baseline and during follow-up in the cohort. Assess the clinical safety of ERCP-GPC and LC by evaluating the clinical success rate of treatment as well as the incidence of short-term and long-term postoperative complications; investigate the efficacy differences among endoscopic transpapillary gallbladder-preserving cholecystolithotomy or ERCP plus laparoscopic cholecystectomy or conservative treatment in managing cholelithiasis with concomitant choledocholithiasis.

NCT Number	NCT07413068
Lead Sponsor	Qilu Hospital of Shandong University Collaborators: The Affiliated Hospital of Qingdao University, Shandong Province Third hospital, Qingdao Municipal Hospital, Shengli Oilfield Hospital, Liaocheng People's Hospital, Binzhou Medical University, Weifang People's Hospital, Taian City Central Hospital, Qianfoshan Hospital, Linyi People's Hospital, Qilu Hospital of Shandong University (Qingdao), Central Hospital of Zibo, The Second Hospital of Shandong University, Dezhou Hospital Qilu Hospital of Shandong University, Rizhao People's Hospital
Conditions	Cholelithiasis Associated With Common Bile Duct Stones
Enrollment	300 participants
Start Date	2025-12-01
Primary Completion	2030-12 (estimated)
Study Completion	2030-12 (estimated)
Updated on ClinicalTrials.gov	2026-05-18