High- and Low-Load Resistance Training

The goal of this clinical trial is to learn whether low-load resistance training performed to muscle failure can produce similar increases in muscle size and strength as high-load resistance training in healthy untrained young adult males. The main questions it aims to answer are: Does low-load resistance training (30% of one-repetition maximum) performed to failure increase muscle strength and muscle size to a similar extent as high-load resistance training (75% of one-repetition maximum)? Are there differences in total training volume between low-load and high-load resistance training programs performed to failure? Researchers will compare a low-load resistance training group to a high-load resistance training group to determine whether the magnitude of changes in muscle strength and hypertrophy differs between the two approaches. Participants will: Be randomly assigned to either a low-load (30% 1RM) or high-load (75% 1RM) resistance training group Perform supervised leg extension exercises to the point of voluntary muscle fatigue three times per week for 6 weeks Complete muscle strength testing (one-repetition maximum) before and after the training period Undergo ultrasound measurements to assess muscle thickness and cross-sectional area of thigh muscles before and after the intervention

NCT Number	NCT07412600
Lead Sponsor	Akdeniz University Collaborators: Selcuk University
Conditions	Resistance Training, Muscle Hypertrophy
Enrollment	22 participants
Start Date	2021-12-18
Primary Completion	2022-06-20 (estimated)
Study Completion	2022-07-02 (estimated)
Updated on ClinicalTrials.gov	2026-02-18