Healing of Apicomarginal Defects Using Autograft or Allograft With Collagen Membrane

Apicomarginal defects, which connect apical and marginal bone loss, are difficult to manage surgically due to their limited regenerative potential. Guided tissue regeneration using grafts and collagen membranes may improve outcomes, but the comparative effectiveness of autografts and allografts in these defects is not well established. This randomized clinical trial at PGIDS Rohtak will evaluate 36 patients undergoing endodontic microsurgery, assigning them to either autograft or allograft combined with a bioresorbable collagen membrane. Clinical and CBCT-based radiographic healing will be monitored over 12 months. The study aims to determine whether allografts can achieve bone regeneration comparable to autografts, offering a less invasive option for treating apicomarginal defects.

NCT Number	NCT07412067
Lead Sponsor	Postgraduate Institute of Dental Sciences Rohtak Collaborators: Post Graduate Institute of Dental Sciences
Conditions	Apicomarginal Defects
Enrollment	50 participants
Start Date	2026-04-01
Primary Completion	2026-05-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-17