PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants

The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks. The main questions it aims to answer are: * What is the role of microbiome maturation in respiratory health (development of bronchopulmonary dysplasia, childhood asthma and viral respiratory infections) of preterm infants ? * Which environmental or health factors are involved in the maturation of the respiratory microbiome ? Participants will undergo follow-up from birth until 3 years of corrected age including nasal swabs, stool samples, and for some of them blood and milk sample.

NCT Number	NCT07411261
Lead Sponsor	University Hospital, Caen Collaborators: INSERM UMR1311 DYNAMICURE
Conditions	Bronchopulmonary Dysplasia, Preterm Infant Development, Asthma Childhood, Bronchiolitis, Viral Respiratory Tract Infections
Enrollment	270 participants
Start Date	2026-03
Primary Completion	2029-03 (estimated)
Study Completion	2031-03 (estimated)
Updated on ClinicalTrials.gov	2026-02-13