Clinical Trial

Microbiome-Targeted Enhancement of Neurocognition With Probiotics-Riboflavin Combination

Study acronym: MENTOR
Not Yet Recruiting
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Summary
This randomized, double-blind, placebo-controlled trial will evaluate whether 12 weeks of supplementation with the probiotic Lactobacillus rhamnosus GG combined with colon-delivered riboflavin will improve cognitive performance and brain physiology in older adults with memory complaints. The study will assess changes in cognitive outcomes together with neurophysiological markers to explore potential gut-brain axis mechanisms. Through its rigorous design, the trial will aim to determine whether targeted modulation of the intestinal environment can support brain function and cognitive health in aging.
Trial Details
NCT Number NCT07410052
Lead Sponsor Center for Health Sciences, Serbia
Conditions Cognitive Deficits, Mild
Enrollment 28 participants
Start Date 2026-04-15
Primary Completion 2027-07-15 (estimated)
Study Completion 2027-08-15 (estimated)
Updated on ClinicalTrials.gov 2026-02-13