A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs

This study includes finalization of the LINKED social network intervention to improve PrEP and MOUD uptake among people who inject drugs (PWID) in collaboration with an Expert Advisory Board and staff (N=16) at The Sidewalk Project (TSP), followed by a Hybrid Type II cluster randomized trial of the LINKED intervention (versus an equal-attention control) among N=372 people who inject drugs, with 6- and 12-month follow-up assessment of PrEP and MOUD uptake. The investigators will also evaluate implementation outcomes to inform future sustainable implementation of LINKED in harm reduction organizations.

NCT Number	NCT07409350
Lead Sponsor	NYU Langone Health Collaborators: National Institute on Drug Abuse (NIDA)
Conditions	Substance Use, HIV Prevention
Enrollment	398 participants
Start Date	2027-01
Primary Completion	2028-12 (estimated)
Study Completion	2028-12 (estimated)
Updated on ClinicalTrials.gov	2026-02-13