Exploratory Randomized, Controlled, Dose-response Study on the Impact of Nicotine From Five Variants of a Nicotine Tablet (NICOTINE TABLET) on Attention

This study aims to provide initial insights into the impact of orally delivered nicotine on attentional performance in adult occasional users of nicotine pouches. Nicotine will be administered via a dissolvable tablet for approximately 10 minutes. The main objective of this exploratory study is to characterize the effect of nicotine on attentional performance, using metrics derived from Continuous Performance Test (CPT). Additionally, a second CPT assessment will be conducted two hours after the first administration to explore the potential sustained effects of nicotine on attention as an exploratory objective.

NCT Number	NCT07408180
Lead Sponsor	Philip Morris Products S.A.
Conditions	Attention
Enrollment	40 participants
Start Date	2025-10-28
Primary Completion	2026-03-16 (estimated)
Study Completion	2026-04-23 (estimated)
Updated on ClinicalTrials.gov	2026-05-05