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The Comparison of Ibandronate and Zoledronic Acid After Denosumab Discontinuation

StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 5 months later Mar 17, 2030 → Aug 31, 2030
See other at-risk trials from National Taiwan University Hospital

Record History

  1. Recruitment opened Start date changed from estimate of Mar 17, 2026 to Aug 20, 2026 · Primary completion pushed from Mar 17, 2030 to Aug 31, 2030 · Completion pushed from Sep 17, 2030 to Oct 31, 2030 · 1 morev2 Show 4 more changesShow less
    • Start date changed from estimate of Mar 17, 2026 to Aug 20, 2026
    • Primary completion pushed from Mar 17, 2030 to Aug 31, 2030
    • Completion pushed from Sep 17, 2030 to Oct 31, 2030
    • Site details revised
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study is a prospective, multicenter, open-label, randomized non-inferiority trial comparing intravenous ibandronate and zoledronic acid as sequential therapy after denosumab discontinuation in postmenopausal women with osteoporosis. This trial primarily targets patients with short-term denosumab exposure (less than three years) and is conducted as a preliminary investigation. The findings are expected to provide foundational evidence to inform the design of future studies assessing sequential therapies following longer-term denosumab treatment.
Trial Details
NCT Number NCT07406685
Lead Sponsor National Taiwan University Hospital
Collaborators: National Taiwan University
Conditions Postmenopausal Osteoporosis, Postmenopausal Osteopenia, Primary Osteoporosis, Osteoporosis
Enrollment 52 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov