Clinical Trial

Entropy-based Physiological Signal Analysis in Patients With Obstructive Sleep Apnoea

Study acronym: EPPOSA

Active, Not Recruiting

Summary

This observational study is being undertaken as a part of a Master of Research (MRes) in Clinical Research programme. Its goal is to learn about how continuous positive airway pressure (CPAP) therapy changes the complexity of body signals in adults with obstructive sleep apnoea (OSA). The main question it aims to answer is: \- How does the complexity of physiological signals (specifically oxygen saturation, heart rate, and heart rate variability) change in adults with OSA from before to after three and six months of CPAP treatment? It will use data from individuals who took part in an earlier trial, called 3DPiPPIn, which tested the use of 3D-printed, customised masks CPAP masks through sleep studies.

Protocol Amendment History 4 changes

critical Trial status changed: Not Yet Recruiting → Active, Not Recruiting 2026-06-17

critical Primary endpoint(s) modified 2026-06-17

notable Enrollment reduced: 160 -> 139 participants 2026-06-17

notable Primary completion pushed: 2026-07 -> 2026-08 2026-06-17

Trial Details

NCT Number	NCT07406620
Lead Sponsor	King's College London Collaborators: Royal Free Hospital NHS Foundation Trust
Conditions	Obstructive Sleep Apnoea (OSA)
Enrollment	139 participants
Start Date	2026-06-11
Primary Completion	2026-08 (estimated)
Study Completion	2026-09 (estimated)
Updated on ClinicalTrials.gov	2026-08-10