Clinical Trial

Correlation Between Tumor-infiltrating Lymphocytes and Response to Systemic Therapy in Breast Cancer

Completed
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Summary
This study aims to investigate the correlation between immune-related factors in the tumor stroma and pathological complete response (pCR) in patients with early breast cancer treated with neoadjuvant chemotherapy. In addition, the study evaluates the association between immune-related tumor stroma factors and the presence of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in peripheral blood. The study includes serial blood sampling before and after treatment and during follow-up to assess the prognostic value of these biomarkers for disease progression and recurrence.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-02-04.
Trial Details
NCT Number NCT07404462
Lead Sponsor Institute of Oncology Ljubljana
Conditions Breast Cancer, Early Breast Cancer
Enrollment 171 participants
Start Date 2017-03-01
Primary Completion 2022-03-01 (estimated)
Study Completion 2022-03-01 (estimated)
Updated on ClinicalTrials.gov 2026-02-19