Clinical Trial

Combined Use of a Respiratory Multiplex PCR and Algorithm-based Therapy to Improve Early Optimization of Antibiotic Therapy in Critically Ill Patients With Ventilator-associated Pneumonia

Study acronym: SMART-VAP
Not Yet Recruiting Phase 4
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Record status
This record was last updated February 12, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
Assess the impact of a strategy combining respiratory mPCR and algorithm-based therapy developed using local epidemiology on the early optimization of initial antibiotic therapy for ventilator-associated pneumonia (VAP) (intervention), compared to a conventional strategy (control). A bicentric, parallel-group, randomized controlled trial. The primary assessment criterion is the proportion of early optimized antibiotic therapy within 24 hours of respiratory sampling.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-02-04.
Trial Details
NCT Number NCT07403474
Lead Sponsor Centre Hospitalier Universitaire de Nīmes
Conditions Ventilator Associated Pneumonia ( VAP)
Enrollment 124 participants
Start Date 2026-06-01
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-12