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Caffeine Strategies and Fat Oxidation

StatusEnrolling by Invitation
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated April 29, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Notable Trial status changed: Not Yet Recruiting → Enrolling by Invitationv2 Show 4 more changesShow less
    • Primary completion pushed from Jun 15, 2026 to Jul 31, 2026
    • Study completion pushed from Jun 16, 2026 to Sep 30, 2026
    • Study sites: 0 to 1
    • Start date changed from estimate of Feb 1, 2026 to Mar 15, 2026
  2. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to learn if different forms of caffeine ingestion can influence fat oxidation during submaximal cycling exercise. The study will recruit healthy adults, both men and women, aged 18 to 50, who regularly perform aerobic exercise. The main questions it aims to answer are: * Does caffeine increase fat oxidation during one hour of cycling at the Fatmax intensity? * Do different forms of caffeine ingestion (capsule, coffee, chewing gum, or mouth rinse) differ in their effect on fat oxidation? * Do these caffeine forms alter total energy expenditure, cardiorespiratory response, or perceived exertion during exercise? * Are there differences in the occurrence or severity of side effects between caffeine administration methods? Researchers will compare each caffeine form to its corresponding placebo to determine their effects on fat oxidation and other physiological outcomes. Participants will: * Attend a pre-experimental session to determine their Fatmax intensity and VO₂max using an incremental cycling test * Perform eight experimental sessions, each consisting of one hour of cycling at Fatmax intensity * Receive caffeine or placebo via capsules, coffee, chewing gum, or mouth rinse according to a randomized, double-blind, crossover design * Be monitored for fat and carbohydrate oxidation, total energy expenditure, heart rate, and perceived exertion during exercise * Report any side effects immediately after the session and 24 hours later using a structured questionnaire All sessions will be conducted under controlled laboratory conditions with standardized protocols to ensure safety and reliable measurements.
Trial Details
NCT Number NCT07402902
Lead Sponsor Universidad Rey Juan Carlos
Conditions
(from sponsor)
Fat Metabolism, Caffeine, Cycling, Exercise, Ergogenics
Related terms Motor Activity
Enrollment 10 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov