Predicting Weight Loss After Pharmacological or Surgical Treatment in Patients With Obesity

As with other nutritional strategies, the clinical response to bariatric surgery can be highly variable, with weight regain being a frequent occurrence. Recent evidence on anti-obesity medication indicate similar inter-individual variability in clinical response. Among multiples factors, co-occurrence of eating disorders such as binge eating disorder has been implicated in insufficient clinical response. Improving our ability to predict how patients will respond to obesity treatment is necessary in order to tailor the care pathways we offer. The mechanisms involved in disturbances of eating behaviour before and after surgery remain largely unknown. This study aims to identify the predictive factors of weight loss after pharmacological or surgical treatment, as well as the cognitive and biological mechanisms that mediate this effect.

NCT Number	NCT07402031
Lead Sponsor	Université Catholique de Louvain
Conditions	Obesity & Overweight
Enrollment	100 participants
Start Date	2026-05-05
Primary Completion	2032-06 (estimated)
Study Completion	2036-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-14