It has been reported that mothers of preterm infants who experience anxiety face challenges in participating in infant care. However, the effect of solution-focused approach on reducing the anxiety of mothers of premature infants is unknown. This study was conducted to assess the effects of Solution-Focused Approach on the anxiety levels of mothers who are anxious about preterm infants care. A randomized controlled trial design. The present study was carried out in the Neonatal Intensive Care Units of three hospitals in a city center. In the study, the sample group was determined as 40 mothers, 20 of whom were interventions and 20 were control. In this study, eight 30-40minute solution-focused interviews were held with the participants in the intervention group subjected to the Solution Focused Approach. Of the mothers in the intervention group, 5% had triplet pregnancy, 75% gave birth by cesarean section, 80% had health problems during pregnancy and 95% did not receive training on infant care during pregnancy. The differences in scale scores obtained during follow-ups were greater in the intervention group than in the control group. It was determined that the intervention undergone by the mothers of the preterm infants in the intervention group decreased the mothers' anxiety levels about infant care and increased their solution-focused coping skills. Following the intervention, moms in the intervention group showed improvement in all of their self-perception skills about their care needs. The Solution-Focused Approach decreased state-trait anxiety levels of mothers who were anxious about preterm infant care, and improved their solution-focused coping skills. The Individual Solution-Focused Approach decreased state and trait anxiety levels of primiparous mothers who were anxious about preterm infant care, and improved their solution-focused coping skills. Nurses' application of this approach can reduce the anxiety levels of mothers who are worried about preterm infant care. It can contribute to mothers to develop a solution-focused perspective.