Short and Long-term Responses of PD Symptoms to Earstim

This is a prospective, multicenter, randomized, two-period study designed to evaluate the safety and effectiveness of the EarStim System for intermittent relief of motor symptoms in patients with Parkinson's disease experiencing wearing-off phenomena. Adult patients with moderate to severe Parkinson's disease (MDS-UPDRS Part III score ≥33) receiving oral dopaminergic therapy will be enrolled. Period A is a randomized, double-blind, sham-controlled phase conducted in a clinical setting. Period B is an unblinded, standard-of-care-controlled phase evaluating the effectiveness of the EarStim System during home use over 90 days.

NCT Number	NCT07400731
Lead Sponsor	Stoparkinson Healthcare Systems LLC
Conditions	PARKINSON DISEASE (Disorder)
Enrollment	90 participants
Start Date	2026-03-12
Primary Completion	2027-01 (estimated)
Study Completion	2027-02 (estimated)
Updated on ClinicalTrials.gov	2026-04-23