Clinical Trial

The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.

Recruiting Early Phase 1
View on ClinicalTrials.gov →
Summary
A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain. The study utilizes statistical methods such as chi-squared, T-tests, and regression analysis, accounting for multiple outcomes with the Bonferroni adjustment. Duloxetine hydrochloride and pregabalin, both available in Bangladesh, are evaluated as experimental drugs, while placebos are used to assess psychological effects on pain. All participants receive standard interventional treatments, with acetaminophen provided as needed, and ethical considerations are addressed according to international guidelines.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-02-09.
Status change: Not Yet Recruiting → Recruiting 2026-02-09
Trial Details
NCT Number NCT07400471
Lead Sponsor Chattogram International Dental College
Conditions Post Endodontic Pain, Mechanical Detection Threshold, Mechanical Pain Threshold, Mechanical Pain Sensitivity
Enrollment 280 participants
Start Date 2026-02-06
Primary Completion 2027-03-30 (estimated)
Study Completion 2027-04-30 (estimated)
Updated on ClinicalTrials.gov 2026-02-11