Gait and Bone Health in SMA

The objective of this study is to understand how spatiotemporal and kinetic gait parameters are associated with bone health in pwSMA who are receiving DMT. We hypothesize that gait parameters are associated with BMD and can determine fracture risk in pwSMA. This is an observational study that involves one in-clinic visit (approximately 3 hours) with remote follow-up visits (approximately 15 minutes) every 3 months for 1 year to collect fracture and medical history. Each of the assessments included in this study are non-interventional and are not intended as a treatment nor are they at the level of standard of care.

NCT Number	NCT07400198
Lead Sponsor	Jacqueline Montes Collaborators: Biogen
Conditions	Spinal Muscular Atrophy Type 3, Ambulatory Spinal Muscular Atrophy
Enrollment	22 participants
Start Date	2026-03-05
Primary Completion	2027-06-30 (estimated)
Study Completion	2027-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-18