Simplified, Scalable, 24-hour Adaptive DBS in Parkinson's Disease

The purpose of this study is to test a new way to treat Parkinson's disease (PD). Subjects will be implanted with deep brain stimulator (DBS) devices and electrodes placed under the scalp. The main questions it aims to answer are: * Is there a less invasive method to collect useful brain signals? Find out if these brain signals can be related to movement and/or sleep symptoms. * How to use these brain signals to tailor adaptive deep brain stimulation settings for movement and/or sleep symptoms Researchers will compare study derived adaptive DBS settings to subject's clinically programmed continuous DBS settings to see which is better at treating patients PD symptoms.

NCT Number	NCT07398157
Lead Sponsor	University of California, San Francisco Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	PD - Parkinson's Disease
Enrollment	24 participants
Start Date	2026-04-09
Primary Completion	2029-11-30 (estimated)
Study Completion	2031-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-05