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Markers of Bone Destruction and Oxidative Stress in Peri-implantitis

StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 3 months later Aug 15, 2026 → Nov 15, 2026
See other at-risk trials from Saglik Bilimleri Universitesi

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary completion pushed from Aug 15, 2026 to Nov 15, 2026
    • Study completion pushed from Sep 15, 2026 to Nov 20, 2026
    • Eligibility criteria revised
    • Secondary endpoints: details revised at 3 of 6 entries
  2. Recruitment opened
    • Study sites: 0 to 1
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.
Trial Details
NCT Number NCT07397884
Lead Sponsor Saglik Bilimleri Universitesi
Conditions
(from sponsor)		 Periodontal Diseases, Periimplant Diseases
Related terms Alveolar Bone Loss, Periodontal Diseases
Enrollment 80 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov