Clinical Trial

Markers of Bone Destruction and Oxidative Stress in Peri-implantitis

Recruiting
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Record status
This record was last updated August 11, 2026 (before its estimated August 15, 2026 completion). Its status may not reflect the trial's current state.
Summary
The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant sulcular fluid (PISF) of patients with peri-implantitis, periodontitis, and healthy individuals. The study seeks to determine the diagnostic value of these biomarkers in the early detection and progression of peri-implant diseases.
Protocol Amendment History 1 change
critical Recruitment opened 2026-08-12
Trial Details
NCT Number NCT07397884
Lead Sponsor Saglik Bilimleri Universitesi
Conditions Periodontal Diseases, Periimplant Diseases
Enrollment 80 participants
Start Date 2026-02-15
Primary Completion 2026-08-15 (estimated)
Study Completion 2026-09-15 (estimated)
Updated on ClinicalTrials.gov 2026-08-11