Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in Thyroidectomy

This randomized controlled trial aims to evaluate the efficacy of intraoperative methylene blue (MB) spray in improving the identification and preservation of the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs) during thyroidectomy. The study compares outcomes between patients receiving topical MB spray and those undergoing conventional visual dissection alone. Primary outcomes include the incidence of RLN injury and postoperative serum calcium levels.

NCT Number	NCT07395388
Lead Sponsor	Services Hospital, Lahore
Conditions	Benign Multinodular Goiter, Thyroidectomy, Recurrent Laryngeal Nerve Injury, Hypoparathyroidism
Enrollment	136 participants
Start Date	2022-01-10
Primary Completion	2025-12-31 (estimated)
Study Completion	2026-01-20 (estimated)
Updated on ClinicalTrials.gov	2026-02-09