Clinical Trial

Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas

Study acronym: SHAFT
Not Yet Recruiting
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Summary
Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas. In particular, it remains unclear whether fertility-sparing surgery for cervical adenocarcinomas - characterized by skip lesions - can ensure optimal disease control while achieving adequate obstetric outcomes. For this reason, a systematic review and meta-analysis of the literature, along with an analysis of our center's data, is warranted. This approach will allow a critical, comparative evaluation of the efficacy of the different techniques (conization, simple trachelectomy, and radical trachelectomy) and the identification of prognostic factors to guide therapeutic choice.
Trial Details
NCT Number NCT07394413
Lead Sponsor Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions Cervical Adenosarcoma
Enrollment 100 participants
Start Date 2026-02-01
Primary Completion 2027-02-01 (estimated)
Study Completion 2027-02-01 (estimated)
Updated on ClinicalTrials.gov 2026-02-06