Short-Course Radiotherapy With Tumor-Draining Lymph Node Preservation Followed by PD-1 Inhibitors in pMMR/MSS Stage II-III Rectal Cancer

This study aims to evaluate the efficacy (pathological complete response rate) of short-course radiotherapy with preservation of tumor-draining lymph nodes followed by sequential PD-1 inhibitor neoadjuvant therapy in patients with stage II-III pMMR/MSS locally advanced rectal cancer.

NCT Number	NCT07394192
Lead Sponsor	Peking University Cancer Hospital & Institute
Conditions	Rectal Cancer, Radiotherapy, PD-1 Inhibitor
Enrollment	44 participants
Start Date	2026-02-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2031-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-06