Clinical Trial

A Prospective Multicenter Cohort Study of Contemporary Menopausal Hormone Therapy and Cardiovascular Outcomes

Study acronym: CATCH-Menopaus
Not Yet Recruiting
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Summary
This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women. Menopause-related estrogen deficiency leads to metabolic and vascular changes that increase atherosclerosis and cardiovascular events. This study hypothesizes that new HRT forms may reduce cardiovascular risk in high-risk women."
Protocol Amendment History 3 changes
notable Enrollment increased: 2725 -> 3408 participants 2026-08-01
notable Primary completion pushed: 2035-03 -> 2041-03 2026-08-01
minor Completion pushed: 2035-03 -> 2041-03 2026-08-01
Trial Details
NCT Number NCT07394049
Lead Sponsor Heinrich-Heine University, Duesseldorf
Conditions Hormone Replacement Therapy, Cardiovascular Diseases, Hormone Replacement Therapy, Post-Menopausal, Menopause
Enrollment 3,408 participants
Start Date 2026-08-01
Primary Completion 2041-03 (estimated)
Study Completion 2041-03 (estimated)
Updated on ClinicalTrials.gov 2026-07-31