CLarifying ABCB1's Role in Alzheimer's Disease

Alzheimer's disease is biologically defined by the accumulation of amyloid beta and tau protein, identified using cerebrospinal fluid biomarkers. The ABCB1 gene, which encodes P-glycoprotein involved in amyloid beta efflux across the blood-brain barrier, may influence Alzheimer's disease risk. We hypothesize that certain functional ABCB1 polymorphisms impair amyloid beta clearance, thereby promoting the development of biologically defined Alzheimer's disease.

NCT Number	NCT07393113
Lead Sponsor	Assistance Publique - Hôpitaux de Paris
Conditions	Alzheimer Disease
Enrollment	510 participants
Start Date	2023-10-25
Primary Completion	2025-12-31 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-06