The aim of this retrospective cross-sectional study was to assess physical activity and sedentary behavior levels in first-year university students and to explore their association with obesity and musculoskeletal health risk indicators. Physical activity and sedentary behavior were assessed using the Global Physical Activity Questionnaire (GPAQ), while body mass index (BMI) was used to classify weight status. Sedentary behavior was interpreted as an indirect indicator of musculoskeletal risk. Understanding these behavioral patterns may help identify at-risk profiles and inform non-invasive prevention strategies in university populations.