Understanding the Role of the Locus Coeruleus in Insomnia

This research project aims to better understand the neurobiological mechanistic underpinnings of insomnia disorder. The main question is whether cortical hyperarousal in individuals with insomnia disorder, measured by electroencephalograhic (EEG) infraslow oscillation coupling of sigma power during non-rapid eye movement (NREM) sleep and theta power during rapid eye movement (REM) sleep, is related to locus coeruleus activity.

NCT Number	NCT07392177
Lead Sponsor	Woolcock Institute of Medical Research
Conditions	Insomnia
Enrollment	15 participants
Start Date	2026-02
Primary Completion	2027-03 (estimated)
Study Completion	2027-03 (estimated)
Updated on ClinicalTrials.gov	2026-02-06