Clinical Trial

Dose De-escalation in Prostate Radiotherapy Using an MR-Linac in Two Fractions

Study acronym: DESTINATION 2
Recruiting
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Summary
The goal of this clinical trial is to find out whether lowering the radiation dose to parts of the prostate without visible tumor on MRI can reduce side effects while still effectively treating prostate cancer in men with low or intermediate-risk prostate cancer. The main questions it aims to answer are: * Does reducing the radiation dose to healthy prostate tissue lower the risk of bowel and urinary side effects? * Can we maintain good cancer control by keeping a high dose for MRI-visible tumor areas? Researchers will compare two treatment approaches: * One group receives a uniform high dose to the entire prostate. * The other group receives a lower dose to healthy prostate tissue and a high dose only to visible tumor areas. Participants will: * Receive two sessions of MRI-guided radiotherapy using an MR-Linac. * Complete questionnaires about urinary, bowel, and sexual health before and after treatment. * Have follow-up visits to monitor side effects and PSA levels for up to 2 years.
Trial Details
NCT Number NCT07391982
Lead Sponsor The Netherlands Cancer Institute
Collaborators: MRL Consortium, Elekta Limited
Conditions Prostate Cancer (Adenocarcinoma)
Enrollment 54 participants
Start Date 2025-11-17
Primary Completion 2027-02 (estimated)
Study Completion 2028-12 (estimated)
Updated on ClinicalTrials.gov 2026-02-06