Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients

AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting. The study targets adult and elderly patients with chronic diseases or immunocompromising conditions who are eligible for vaccination according to national immunization guidelines. Vaccination is actively proposed during outpatient visits, hospital admissions, or at discharge and, when accepted, administered within the hospital or coordinated with local public health vaccination services. The study aims to evaluate the feasibility, uptake, and completion of hospital-based vaccination pathways and to support integration between hospital and territorial prevention services for vulnerable populations.

NCT Number	NCT07391046
Lead Sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS Collaborators: Pfizer
Conditions	Chronic Disease, Immunocompromised, HIV Infection, Chronic Kidney Disease, Solid Organ Transplantation, Hematopoietic Stem Cell Transplantation, Cancer, Autoimmune Diseases +3 more
Enrollment	1,500 participants
Start Date	2026-02
Primary Completion	2027-02 (estimated)
Study Completion	2027-02 (estimated)
Updated on ClinicalTrials.gov	2026-02-05