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Feasibility of Integrating Olfactory Stimuli Into Virtual Reality Cue Exposure for Patients With Alcohol Dependence

StatusRecruiting
PhaseNot applicable
Started2026-03-07
View on ClinicalTrials.gov ↗
Record status
This record was last updated June 23, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2026-06-21
Study Status v4
Primary completion pushed: 2026-05-31 → 2026-07-31
Completion pushed: 2026-05-31 → 2026-07-31
2026-05-10
Study Identification, Study Status v3
Re-verified, no change to tracked fields
2026-04-07
Study Status, Contacts/Locations v2
Recruitment opened
Start dateestimated 2026-02-01→confirmed 2026-03-07
Study sitesdetails revised at 1 of 1 site
2026-02-22
Study Identification, Study Status, Sponsor/Collaborators, Study Description, Study Design, Arms and Interventions, Outcome Measures, Eligibility v1
PhaseNot specified→Not applicable
Study arms0→1
InterventionsVR Cue-Exposure Including Olfactory Cues (Device)→VR Cue-Exposure Including Olfactory Stimuli (Device)
Secondary endpoints1 entry, revised
Assessment of Initial Clinical Efficacy of Integrating Olfactory CuesStimuli Into Virtual Reality Cue Exposure
Primary endpoints3 entries, revised
Acceptability of Integrating Olfactory CuesStimuli Into Virtual Reality Cue Exposure Feasibility of Integrating Olfactory CuesStimuli Into Virtual Reality Cue Exposure Tolerability of Integrating Olfactory CuesStimuli Into Virtual Reality Cue Exposure
Study description+17 characters
[...] eality (VR) scenarios combined with corresponding olfactory cuesstimuli: a neutral VR scenario with neutral visual and olfactory cuesstimuli (rose), and an alcohol-related VR scenario with alcohol-related visual and olfactory cuesstimuli (beer, white wine, red wine, vodka, schnaps). The VR-CE pro [...] l be presented in a randomized order, each pairing a visual cuestimuli with the corresponding olfactory cuestimuli for a specific beverage.
Study title+3 characters
Feasibility of Integrating Olfactory CuesStimuli Into Virtual Reality Cue Exposure for Patients With Alcohol Dependence
2026-01-28
Original filing
Alcohol dependence (AD) is a prevalent and burdensome clinical condition with high relapse rates. A central risk factor for relapse is craving for alcohol, which can be evoked by both real-world and virtual cues in immersive Virtual Reality (VR). In addition to visual and auditory stimuli, olfactory stimuli are increasingly recognized as important for creating realistic, multisensory VR environments. However, no systematic investigation has yet examined how olfactory stimuli embedded in VR-based Cue Exposure (VR-CE) influence cue-elicited craving. As part of the OLFA-VR (Effects of Olfactory Stimuli in Virtual Reality Cue Exposure on Craving in Alcohol Dependence) research project, the present feasibility study aims to evaluate the feasibility, tolerability and acceptability of implementing olfactory stimuli into VR-CE. In addition, this study not only examines the general feasibility of alcohol-related olfactory stimuli in VR-CE but also explores which specific alcohol-related olfactory stimuli prove to be feasible. The investigators hypothesize that implementing olfactory stimuli into VR-CE will be feasible and tolerable for patients with AD, with no preventable serious side effects caused by VR-CE. The investigators also hypothesize that VR-CE will induce craving in most patients.
Trial Details
NCT Number NCT07388693
Lead Sponsor Charite University, Berlin, Germany
Conditions Alcohol Dependence
Enrollment 20 participants
Start Date 2026-03-07
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-06-23