Role of Exercise in PRISm and Subsequent Development of COPD

Preserved Ratio Impaired Spirometry (PRISm) describes individual with spirometry findings of forced expiratory volume (FEV1) and forced vital capacity (FVC) ratio greater than 0.7 but with the FEV1 less than 80% predicted. While the spirometry findings of individuals with PRISm can be transited into obstructive pattern, remains at PRISm or become normal spirometry, limited evidence is on the role of exercise in the course of PRISm. This study aims to investigate the role of exercise, namely exercise with telehealth and walking exercise, together with smoking cessation advice, would alter the clinical course of PRISm.

NCT Number	NCT07387432
Lead Sponsor	The University of Hong Kong Collaborators: Queen Mary Hospital, Hong Kong
Conditions	Preserved Ratio Impaired Spirometry (PRISM)
Enrollment	90 participants
Start Date	2025-07-14
Primary Completion	2027-01 (estimated)
Study Completion	2028-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-06