Clinical Trial

Development of a Novel Graded Prognostic Assessment (BC-LGPA) Model for Breast Cancer Leptomeningeal Metastasis

Completed
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Summary
The investigators conducted a large, multicenter retrospective study of patients with breast cancer leptomeningeal metastasis (BCLM), constituting one of the largest and most comprehensively curated cohorts to date. Data from 403 patients diagnosed between November 2013 and November 2025 were collected from three major academic centers. Detailed clinical, pathological, diagnostic, and treatment data were analyzed. Overall survival (OS) was evaluated, and independent prognostic factors were identified via Cox regression. A novel Breast Cancer Leptomeningeal Graded Prognostic Assessment (BC-LGPA) model was developed and validated for risk stratification.
Trial Details
NCT Number NCT07386886
Lead Sponsor Jian Zhang,MD
Conditions Leptomeningeal Metastasis in Breast Cancer
Enrollment 403 participants
Start Date 2013-11-30
Primary Completion 2025-11-30 (estimated)
Study Completion 2026-01-26 (estimated)
Updated on ClinicalTrials.gov 2026-02-04