Study of Imaging and Molecular Biomarkers in Uncomplicated Rhegmatogenous Retinal Detachment

Disease or general study area: Uncomplicated rhegmatogenous retinal detachment (RRD) and risk of proliferative vittroretinopathy (PVR) Purpose and nature of the study: 1. Characterise the cytokine profile of vitreous fluid in uncomplicated RRD. 2. Develop a risk model to predict development of PVR after retinal detachment surgery using imaging and molecular biomarkers. 3. To develop deep learning/artificial intelligence (AI) models for PVR detection in retinal detachment. Inclusion criteria: 50 adult ( ≥18 years) patients with uncomplicated rhegmatogenous retinal detachments without PVR. What participating will involve: Pre- and post-operative assessments and intervention will follow standard of care for patients with rhegmatogenous retinal detachments. Additional intervention will include non-invasive imaging of anterior chamber flare, vitreous, wide-field retina, macula optical coherence tomography (OCT) and macula OCT-angiography (OCT-A) as well as, seeking participant's consent on collecting their vitreous fluid at time of their surgery for cytokine analysis.

NCT Number	NCT07386678
Lead Sponsor	University College, London
Conditions	Retinal Detachment Rhegmatogenous, Proliferative Vitreoretinopathy, Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
Enrollment	50 participants
Start Date	2026-04-27
Primary Completion	2027-01-27 (estimated)
Study Completion	2027-01-27 (estimated)
Updated on ClinicalTrials.gov	2026-05-06