Clinical Trial

Daily Fluctuations in Brain-Derived Neurotrophic Factor and Cognition: Effects of Vigorous Exercise

Completed
View on ClinicalTrials.gov →
Summary
Cognitive functions are fundamental to everyday life, underpinning the mental processes required to perform any activity. Recent studies have shown that improved cognitive performance is associated with elevated levels of brain-derived neurotrophic factor (BDNF), which can be increased through an acute bout of physical activity. However, daily variations of BDNF serum and plasma remain poorly characterised and are not fully understood, and their correlation with daily variations in cognitive performance has not been previously explored. This study examines: 1\) the correlation between daily BDNF fluctuations and cognitive performance. 2) whether a single session of exercise can elevate BDNF levels and lead to measurable cognitive improvements.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-01-26.
Trial Details
NCT Number NCT07385118
Lead Sponsor University of Padova
Conditions BDNF
Enrollment 15 participants
Start Date 2025-12-01
Primary Completion 2025-12-23 (estimated)
Study Completion 2025-12-23 (estimated)
Updated on ClinicalTrials.gov 2026-02-09